Cellagon aurum is active health protection
Results of the current in-vivo study* (2009)

*

In science one describes processes that take place in the living organism as being "in vivo" (Latin for "in the living"). In contrast to this, processes that take place in an artificial environment (e. g. test tube) or just generally outside of living organisms, are termed as "in vitro".

Cellagon aurum, a complex food product with 77 ingredients from 17 ingredient groups such as fruit, vegetables, herbs, algae, fungi, oils and many others, is rightly translated as "Cell Gold", because it provides the body in a significant way with important bio-active substances and cell-protecting antioxidants. This was manifested by an in-vivo study commissioned by the company Hans-Günter Berner GmbH & Co. KG. The study showed a scientifically strong (significant to highly significant) increase or rather absorption of selected vitamins from the colon into the bloodstream and a significant improvement of the protection system of the cell tissues. Below is a short summary of the most important questions and answers regarding the study.

1. Which parameters were measured?

At the Institute for Nutritional Sciences at the Friedrich Schiller University in Jena the absorption of selected parameters from the colon into the bloodstream (the so-called intestinal absorption) was examined under strict, scientific criteria. This is a partial aspect of the bioavailability, but is not synonymous with it. The bioavailability in its full range can only be determined by examining tissue samples of each of the target tissues. This means: biopsies (= tissue sampling) would have to be carried out which is hardly feasible in studies from a practical point of view and is also not allowed for the food industry.

The aim of the in-vivo study was now to research into the extent to which the selected nutrients vitamins C and E are absorbed from the natural compound of Cellagon aurum. In other words: "To what extent does the vitamin C and E content in the blood plasma increase after digestion?"

In addition, the antioxidative capacity of Cellagon aurum was examined. Antioxidants are important substances that can be found to a great extent in various types of fruit and vegetables, but also in oils. They protect the cells against oxidative damage that can be caused by free radicals. A proven test pattern in this case is the observation of the protection systems. A differentiation is made here between two protection systems with antioxidative effect: a water-soluble (H-TEAC) and a fat-soluble (L-TEAC) system. Here TEAC designates the measuring method and the letter "H" preceding it stands for hydrophilic (= water-soluble) and "L" for lipophilic (= fat-soluble). The water-soluble protection systems can mainly be found in the intercellular area (= interstitial fluids) and in the intracellular area (= cytosol or cellular fluid), the fat-soluble protection systems in the cell membranes of all organs. Here, too, the study was restricted for legal reasons to the examination medium "blood" as the taking of tissue samples is not allowed.

For the sake of completeness the body's own antioxidant "uric acid" was also examined as the literature points out that uric acid is also said to influence antioxidant protection systems.

Below the examination parameters are listed once more in detail:

  1. Vitamin C in the blood plasma
  2. Vitamin E in the blood plasma
  3. Water-soluble, hydrophilic protection system (H-TEAC)
  4. Fat-soluble, lipophilic protection system (L-TEAC)
  5. Uric acid in the blood plasma

2. How was the study designed?

The study was designed according to the "gold standard" of study planning: double blind, cross-over, randomised and controlled. Before commencing the study, all test persons were subjected to a so-called washout phase. They had to follow a strict diet that excluded any foods rich in vitamins. The aim was to reach an almost uniform nutrient status in all participants. The test persons were divided into two groups (Group A and B) and each consumed 2 × 10 ml of a drink mixed with water (Cellagon aurum in Bottle 1 and a placebo in the form of a multi-vitamin juice in Bottle 2). Neither the examination staff (doctor and scientists) nor the test persons knew which substance had just been consumed.

Before (T -2) and after (T 0) the washout phase the first fasting blood samples were taken and the following 2-week intervention phase (= consumption of Cellagon aurum or placebo) begun. Also during these 2 weeks the test persons adhered to a prescribed diet. Fasting blood samples were taken in the morning after each week (T 1 und T 2). Then followed a 2-week interval during which the test persons were able to eat a normal diet and did not need to drink any Cellagon aurum or placebo. After 6 weeks the whole examination process began over again: 2 weeks washout phase - but with the difference that Group A did not drink Bottle 1 but received the drink in Bottle 2 and vice versa for Group B.

The following diagram illustrates the test arrangement:

Test arrangement

3. What were the results of the study?

The analyses of the content of vitamin C and vitamin E in the blood plasma showed that both vitamins of which more than the recommended daily intake was contained in the consumed portion, were absorbed. The vitamin C in the blood increased very significantly and the vitamin E content was just under the significance limit of 0.05 (Cellagon aurum value = 0.053).

The uric acid values did not change after consuming Cellagon aurum.

In the blood plasma it was also possible to confirm the positive influence of Cellagon aurum on hydrophilic and lipophilic antioxidant protection systems.

The water-soluble protection system (= hydrophilic AOX) very rapidly absorbs nutrients, but excretes them just as rapidly again (within 5 hours). After the fasting blood sampling in the mornings, the hydrophilic AOX showed a slight tendency to increase but this is not significant.

Thanks to drinking Cellagon aurum a significant increase in the fat-soluble protection system (= lipophilic AOX) could be determined. In the blood the lipophilic protection system already ensures protection of the fatty cell membrane and the lipoproteins (= protein fat, like e. g. the good cholesterol HDL) existing in the blood. As all cells of the body are supplied via the blood, the lipophilic AOX has an indirect influence on many decisive protective mechanisms in the body.

Overview of all results:

Overview of all results

In summary one can say:

The selected nutrients in Cellagon aurum are well absorbed by the body: vitamin C very significantly and Vitamin E just under the significance limit. The protection systems of the blood also examined resulted in a significant increase in the lipophilic protection system (= protection system of the cell tissue).

Conclusion

Cellagon aurum as a balanced, nature-oriented and fluid food product is advantageous to the human organism as cell nutrition in the best sense of the word. It supplies the cells, in particular the cell membranes, with protective substances and therefore protects them against oxidation. In other words one can say that Cellagon aurum contributes positively towards sustaining good health.

July 2009
With the kind support of PH Dr. Volker Böhm, Friedrich Schiller University, Jena

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